Mukerji is a trained Odissi dancer, and began learning the dance in tenth grade. Mukerji studied at Maneckjee Cooper High School in Juhu, and later enrolled at Mithibai College in Mumbai.

While in school at the age of 14, Mukerji did a cameo role in her father’s Bengali film Biyar Phool (1992). In 1994, Salim Akhtar, a family friend, offered her a film called Aa Gale Lag Jaa (1994) but her father was against it as she was too young. Mukerji turned down the offer and Urmila Matondkar was cast instead.

Two years later, Salim Akhtar came up with another offer and insisted on her playing the protagonist of Raja Ki Ayegi Baraat (1997). After a long discussion with her father, she agreed to do the film. When the film was unsuccessful at the box office, Mukerji returned to college to complete her education.

1. Saawariya (2007) (post-production)
2. Laaga Chunari Mein Daag (2007)
3. Ta Ra Rum Pum (2007) (as Rani Mukerji)
4. Baabul (2006) (as Rani Mukerji)
5. Kabhi Alvida Naa Kehna (2006) (as Rani Mukerji)
6. The Rising: Ballad of Mangal Pandey (2005) (as Rani Mukerji)
7. Paheli (2005) (as Rani Mukerji)
8. Bunty Aur Babli (2005) (as Rani Mukerji)
9. Black (2005) (as Rani Mukerji)
10. Veer-Zaara (2004) (as Rani Mukerji)
11. Hum Tum (2004) (as Rani Mukerji)
12. Yuva (2004) (as Rani Mukerji)
13. LOC: Kargil (2003) (as Rani Mukherji)
14. Kal Ho Naa Ho (2003) (as Rani Mukerji)
15. Chori Chori (2003)
16. Calcutta Mail (2003)
17. Chalte Chalte (2003) (as Rani Mukherji)
18. Chalo Ishq Ladaaye (2002) (as Rani Mukherji)
19. Saathiya (2002) (as Rani Mukerji)
20. Mujhse Dosti Karoge! (2002)
21. Pyaar Diwana Hota Hai (2002) (as Rani Mukherji)
22. Nayak: The Real Hero (2001) (as Rani Mukherji)
23. Bas Itna Sa Khwaab Hai (2001) (as Rani Mukherji)
24. Chori Chori Chupke Chupke (2001)
25. Kahin Pyaar Na Ho Jaaye (2000)
26. Bichhoo (2000) (as Rani Mukherji)
27. Hadh Kar Di Aapne (2000)
28. Hey Ram (2000)
29. Badal (2000)
30. Hello Brother (1999)
31. Mann (1999)
32. Mehndi (1998) (as Rani Mukherji)
33. Kuch Kuch Hota Hai (1998) (as Rani Mukherji)
34. Ghulam (1998)
35. Raja Ki Ayegi Baraat (1997)